The electrical sign units off a collection of occasions that lead to crossbridge cycling between myosin and actin, which generates force. The collection of occasions is slightly completely different between skeletal, easy and cardiac muscle. This hole is known as the synapse. The neurotransmitter crosses the gap, binds to a protein (receptor) on the muscle-cell membrane and causes an motion potential within the muscle cell. The action potential rapidly spreads along the muscle cell and enters the cell through the T-tubule. The action potential opens gates within the muscle's calcium retailer (sarcoplasmic reticulum). Calcium ions movement into the cytoplasm, which is where the actin and myosin filaments are. Calcium ions bind to troponin-tropomyosin molecules situated in the grooves of the actin filaments. Normally, the rod-like tropomyosin molecule covers the websites on actin where myosin can kind crossbridges. Upon binding calcium ions, troponin changes shape and slides tropomyosin out of the groove, exposing the actin-myosin binding sites. Myosin interacts with actin by cycling crossbridges, as described previously.

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